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K, Zamudio, A. I, Sharp, P. Pol II phosphorylation regulates a switch between transcriptional and splicing condensates.
Nature Our studies of super-enhancers and their associated biomolecular condensates have led to new approaches to anti-cancer drugs.
These oncogenic super-enhancers can encompass exceptionally large domains, sometimes spanning more than kb, and are highly vulnerable to transcriptional inhibitors that target BRD4 and CDK7.
Normal cells appear to be relatively insensitive to inhibitors that target BRD4 and CDK7, suggesting that transcriptional inhibitors of this type may be useful for cancer therapy Bradner et al.
The vulnerability of large oncogenic super-enhancers may be due to the selective concentration of drugs in super-enhancer condensates at oncogenes Klein et al.
We are now investigating how specific functional groups in small molecules provide drugs with the ability to concentrate within specific compartments in cells.
Selective inhibition of tumor oncogenes by disruption of super-enhancers. Kwiatkowski, N. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.
Bradner, J. Transcriptional addiction in cancer. Klein, I. Partitioning of cancer therapeutics in nuclear condensates.
Science — PMID: Postdocs Isaac Klein and Ann Boija discuss their discovery that cancer therapeutics selectively partition in nuclear condensates.
Our studies have revealed roles for specific chromosome structures in regulation of gene expression in healthy cells and in cancer.
We found that DNA loops between the enhancers and core promoters of active genes are formed and maintained by Mediator and cohesin in mammalian cells Kagey et al.
In cancer, disruption of these regulatory chromosome structures occurs at driver oncogenes and contributes to their dysregulation Hnisz et al.
We also discovered that the transcription factor YY1 contributes to enhancer-promoter interactions by forming multimers analogous to the CTCF-CTCF interactions that contribute to chromosome neighborhoods Weintraub et al.
These studies provide a foundation for our current studies of the relationships between chromosome structure and gene control in development and disease.
Kagey, M. J, Bilodeau, S. Mediator and cohesin connect gene expression and chromatin architecture. Dowen, J.
Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes. S, Day, D. P, Sigova, A. Activation of proto-oncogenes by disruption of chromosome neighborhoods.
Weintraub, A. YY1 is a structural regulator of enhancer-promoter loops. MeCP2 methyl CpG binding protein 2 is a key component of constitutive heterochromatin, which plays important roles in chromosome maintenance and transcriptional silencing.
Mutations in MeCP2 cause Rett syndrome RTT , a postnatal progressive neurodevelopmental disorder associated with severe mental disability and autism-like symptoms that manifests in girls during early childhood.
We found that MeCP2 is a dynamic component of heterochromatin condensates in cells and that both its DNA-binding domain and its C-terminal intrinsically disordered domain contribute to condensate formation Li et al.
MeCP2 manifests physicochemical properties that selectively concentrate heterochromatin cofactors compared to components of transcriptionally active condensates, and when altered by RTT-causing mutations, is disrupted in its ability to form condensates.
We are now studying the properties of nuclear condensate-promoting proteins such as MeCP2 to determine if their physicochemical properties contribute to the separation of euchromatic and heterochromatic condensates, and thereby ensure transcriptional silencing of heterochromatin.
Li, C. MeCP2 links heterochromatin condensates and neurodevelopmental disease. We are scientists with diverse backgrounds and affiliations that bring rich experience to our laboratory and community.
Our collective training is in basic biology, chemistry, physics, computing and medicine. We strive to contribute to our community and advance a new generation of scientific leaders.
Victoria is a senior neurosurgery resident physician at MGH. She is currently performing a research fellowship in the Young lab characterizing the epigenomic drivers of meningioma formation, with the goal of identifying novel medical treatments for patients with brain tumors.
My goal is to identify altered nuclear condensate properties in disease, including cancer and type 2 diabetes. I am a cellular and molecular biologist with an emphasis on human genetics, gene regulation, and the genetic basis of human disease.
My current research goals are to identify the master gene regulatory pathways that control human glial cell identity and state, and to use this information to produce superior stem cell-based models of human glia to study neurodegenerative disease.
I am a stem cell and molecular biologist exploring how RNA regulates biomolecular condensates and gene expression in both native and disease states.
I am interested in quantifying the chemical features and properties underlying the complex thermodynamic and kinetic phenomenon of condensate molecular grammar.
I am a molecular biologist who has a background in gene regulation, chromatin biology and epigenetics.
My research focuses on understanding i how RNA regulates transcription by dynamically controlling transcriptional condensates and ii how RNA-mediated control of transcription could be leveraged in treatment of human diseases.
Mediator condensates localize signaling factors to key cell identity genes. Mol Cell Regulation and dysregulation of chromosome structure in cancer.
Ann Rev Cancer Biol. Science , , eaar Schuijers, J. Transcriptional dysregulation of MYC reveals common enhancer-docking mechanism.
Cell Reports Insulated neighborhoods: structural and functional units of mammalian gene control. C, Sharp, P. Transcription factor trapping by RNA in gene regulatory elements.
Wang, Y. Cell — Super-enhancers in the control of cell identity and disease.Richard Yong ist ein malaysischer Geschäftsmann und Pokerspieler. Richard Yong (* Dezember ; eigentlich Seng Chen Yong) ist ein malaysischer Geschäftsmann und Pokerspieler. Wai Kin Yong (* 7. November ) ist ein malaysischer Pokerspieler. Er ist der Sohn von Richard Yong. Inhaltsverzeichnis. 1 Pokerkarriere. Werdegang. High Roller Series in Montenegro gab es eine faustdicke Überraschung. Der schwerreiche Poker-Amateur und Triton-Macher Richard Yong hat das NLH. Richard Yong | Sydney, Australia | General Manager Tech and Cyber Risk 2nd Line | + connections | View Richard's homepage, profile, activity, articlesTitle: General Manager Tech and Cyber . others named Richard Yong are on LinkedIn. See others named Richard Yong Richard’s public profile badge. Include this LinkedIn profile on other websites. Richard Yong. System Administration Manager at Bank of China (Hong Kong) belize-development.com: System Administration Manager at . Education PhD, , Yale University BS, , Biological Sciences, Indiana University Research Summary We use experimental and computational technologies to determine how signaling pathways, transcription factors, chromatin regulators and small RNAs regulate gene expression in healthy and diseased cells. Our interests range from the basic molecular mechanisms behind gene control to drug. Science, eaar Phillip A. Selective inhibition of tumor oncogenes by disruption of super-enhancers. Kwiatkowski, N. Phillip A. Mediator and cohesin connect gene Eminem Genre and Wett Seiten architecture. Whyte, W. Linda Griffith MIT. She is currently performing a research fellowship Richard Yong the Young lab characterizing the epigenomic drivers of meningioma formation, with the goal of identifying novel medical Autobahn Spiele Kostenlos for patients with brain tumors. Heterochromatic condensates and neurodevelopmental disease MeCP2 methyl CpG binding protein 2 is a key component of constitutive heterochromatin, which plays important roles in chromosome maintenance and transcriptional silencing. YY1 is a structural regulator of enhancer-promoter loops. Drug partitioning in condensates Our studies of super-enhancers and their associated biomolecular condensates have led Strippoker new approaches to anti-cancer drugs. Sizzling Hot Online Echtgeld Jones and the Last Crusade Fedora. Richard A. Young explores how and why gene expression differs in healthy versus diseased cells. Phone. WI Office. [email protected] Email. Lab Website. Richard Yong in the US. We found 7 records in 9 states for Richard Yong in the US. The top state of residence is California, followed by Illinois. The average Richard Yong is around 54 years of age with around 60% falling in to the age group of Of course the subject matter is the infamous Richard Yong who was the director/chairman and erstwhile pal of Mr. T.T. Durai of the now unforgettable NKF Saga. The Saga that is the mother of all Sagas, the one that takes the cake, the one that was supposed to teach lessons how not to kick your own b#lls bacause it can HURT!. Seng Chen "Richard" Yong (born 25 December ) is a Malaysian businessman and poker player. Richard Yong's Results, Stats. AKA Richard Yong. Date Country Watch Place Prize GPI Points; Mar Russia: $ , No Limit Short Deck Hold'em partypoker LIVE - partypoker MILLIONS Sochi Super High Roller Series, Sochi.